- Acute- Elevated PaCO2 (above 6.3kPa) plus Acidosis (pH <7.35)
- Chronic/ Compensated- Elevated PaCO2 (above 6.3kPa) with Renal/ Bicarbonate compensation (elevated HCO3)
- Central Respiratory Depression
- Neuromuscular Disease- Myasthenia Gravis, Muscular Dystrophy
- Obesity Ventilation Syndrome (Pickwickian Syndrome)
Metabolic generation of CO2 is normally removed by ventilation. Changes in ventilation affect the rate of CO2 removal, and lead to a buildup in the blood.
CO2 is readily converted into HCO3-, which is acidic.