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Respiratory Acidosis

From Mediwikis


  • Acute- Elevated PaCO2 (above 6.3kPa) plus Acidosis (pH <7.35)
  • Chronic/ Compensated- Elevated PaCO2 (above 6.3kPa) with Renal/ Bicarbonate compensation (elevated HCO3)


  • Central Respiratory Depression
    • Neuromuscular Disease- Myasthenia Gravis, Muscular Dystrophy
  • Obstruction
  • Obesity Ventilation Syndrome (Pickwickian Syndrome)

Physiological Response

Metabolic generation of CO2 is normally removed by ventilation. Changes in ventilation affect the rate of CO2 removal, and lead to a buildup in the blood.

CO2 is readily converted into HCO3-, which is acidic.