You're browsing as an anonymous user. Join the community today to view notes at your university, edit pages, and share knowledge!

Coeliac Disease

From Mediwikis

The gliadin portion of gluten provokes an autoimmune response in small intestine, leading to villous atrophy, flattening of the mucosa, and a reduced ability to absorb nutrients from food. There is a certain heritability to the disease, with a 1/10 chance of developing it, if a first degree relative has it.


Typically begin at 8–24 months when the child is weaned onto gluten-containing foods, however it is most commonly diagnosed in adults between the ages of 40 and 50. Children:

  • Weight Faltering
  • Abdominal distension
  • Mouth ulcers
  • Abnormal stools- pale, loose, steatorrhoea.


  • Fat soluble vitamin deficiencies- A,D, E and K.
  • Anaemia
  • Intermittent abdominal pain
  • Excess flatulence
  • Weight loss


  • IgA transgluaminase antibodies as a screen
  • Endoscopy with small intestine biopsy:
    • Villous atrophy
    • Crypt Hypertrophy


The only solution is a Gluten Free diet. Failure to comply can lead to relapse of symptoms.

  • Avoid wheat, rye, barley
  • Gluten challenge later in life, to confirm diagnosis