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Autoimmune Liver Disease

From Mediwikis

Important to take a FH on other types of autoimmune disease if you suspect a patient has autoimmune liver disease, especially thyroid disease, RA, pernicious anaemia and Sjorgen’s syndrome.

Autoimmune Hepatitis

Autoimmune disease attaching hepatocytes, leading to inflammation that may progress to cirrhosis.

Epidemiology

M:F ratio is 2:3 Can occur at any age, therefore not unusual to see it in young patients

Presentation

Can either present as acute Hepatitis:

  • Fever
  • Jaundice
  • Abdo pain
  • Hepatomegaly

or with chronic liver disease:

  • Cirrhosis
  • Portal hypertension
  • Low albumin
  • Spider naevi

Investigations

  • Diagnosis require liver biopsy
  • SMA +ve (smooth muscle antibody)
  • +/- ANA +ve
  • Raised IgG is common

These three serum results are characteristic of the classic type of autoimmune hepatitis, however, other types with different diagnostic patterns exist.