Autoimmune Liver Disease
Important to take a FH on other types of autoimmune disease if you suspect a patient has autoimmune liver disease, especially thyroid disease, RA, pernicious anaemia and Sjorgen’s syndrome.
Autoimmune disease attaching hepatocytes, leading to inflammation that may progress to cirrhosis.
M:F ratio is 2:3 Can occur at any age, therefore not unusual to see it in young patients
Can either present as acute Hepatitis:
- Abdo pain
or with chronic liver disease:
- Portal hypertension
- Low albumin
- Spider naevi
- Diagnosis require liver biopsy
- SMA +ve (smooth muscle antibody)
- +/- ANA +ve
- Raised IgG is common
These three serum results are characteristic of the classic type of autoimmune hepatitis, however, other types with different diagnostic patterns exist.